Influenza: one or two more questions

Influenza: one or two more questions

Received wisdom has it that pathogens are not generally lethal to the hosts they normally infect, because they could not survive if they were. Pathogenicity thus becomes adapted to a level at which the host survives to become reinfected (or to produce young that become infected). The most notable example of such adaptation is in the herpesviruses, which have evolved a quite extraordinary repert...

Two (or more) heads are better than one.

Genetics of hypertrophic cardiomyopathy: one, two, or more diseases?

PURPOSE OF REVIEW Hypertrophic cardiomyopathy is the most common identifiable cause of sudden death in the young. This review details the history of hypertrophic cardiomyopathy, recent discoveries in its genetic underpinnings and important genotype-phenotype relationships described in recent studies. RECENT FINDINGS Since the discovery of the genetic underpinnings of hypertrophic cardiomyopat...

Galectin-3 in Heart Failure: More Answers or More Questions?

H eart failure, classically defined as the heart’s inability to “pump blood at a rate commensurate with the requirements of metabolizing tissue,” has long been considered a disease of the myocardium. With improved understanding of the molecular mechanisms of heart failure, it is increasingly clear that heart failure is a systemic disorder and results from the complex interplay between numerous ...

Screening for hazardous or harmful drinking using one or two quantity-frequency questions.

AIMS To address the accuracy of quantity-frequency (QF) questions in screening for hazardous or harmful drinking. METHODS Three groups were interviewed: patients presenting to emergency departments for care of an acute injury (n = 1537) or a medical illness (n = 1151), and community controls interviewed by telephone (n = 1112). The first question about alcohol was a single alcohol screening q...